Four off, about to cause uproar (6)
I believe the answer is:
furore
'uproar' is the definition.
(synonyms)
'four off about' is the wordplay.
'off' indicates an anagram.
'about' becomes 're' ('re' means regarding or about).
'four' is an anagram of 'furo'.
'furo'+'re'='FURORE'
'to cause' is the link.
(Other definitions for furore that I've seen before include "Turmoil, uproar" , "Commotion - public outburst - rage" , "To-do" , "Public fuss" , "An uproar of fury or enthusiasm" .)