Frasier's ex-wife on "Frasier" (6)
I believe the answer is:
lilith
'frasier's ex-wife on frasier' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for lilith that I've seen before include "Adam's first wife? - Frasier Crane's second ex-wife" , "In Jewish myth, Adam's first wife before Eve" , "In some sources she was the first wife of Adam" , "Witch" , "In Jewish folklore, Adam's first wife before Eve" .)