Frenzied comedian's crazy (8)
I believe the answer is:
demoniac
'frenzied' is the definition.
(thesaurus)
'comedian's crazy' is the wordplay.
'crazy' indicates anagramming the letters.
'comedian' anagrammed gives 'DEMONIAC'.
(Other definitions for demoniac that I've seen before include "Person possessed by an evil spirit" , "Comedian of frenzied sort" , "Comedian of develish kind" , "Diabolical" , "man possessed" .)