Frenzied woman, European, American rebuffed (6)
I believe the answer is:
maenad
'frenzied woman' is the definition.
(I've seen this in another clue)
'european american rebuffed' is the wordplay.
'european' becomes 'Dane' (someone from Denmark).
'american' becomes 'Am' (abbreviation in some contexts).
'rebuffed' is a reversal indicator.
'dane'+'am'='daneam'
'daneam' backwards is 'MAENAD'.
(Other definitions for maenad that I've seen before include "Woman possessed" , "A raging woman, once a follower or Dionysus" , "Bacchante" , "Frenzied female" , "woman in a frenzy" .)