Fresh cream in a fool's second drink (9)
I believe the answer is:
americano
'drink' is the definition.
(type of coffee drink)
'fresh cream in a fool's second' is the wordplay.
'fresh' indicates an anagram.
'fool's second' becomes 'o' (2nd letter of 'fool').
'cream'+'in'+'a'='creamina'
'creamina' anagrammed gives 'american'.
'american'+'o'='AMERICANO'
(Other definitions for americano that I've seen before include "Style of coffee" , "Espresso diluted with hot water" , "drink" .)