Fretted, perhaps ached to get out of the welfare centre (6)
I believe the answer is:
chafed
'fretted' is the definition.
('chafe' can be a synonym of 'fret')
'perhaps ached to get out of the welfare centre' is the wordplay.
'perhaps' is an anagram indicator.
'to get' indicates putting letters inside.
'out of the welfare centre' becomes 'f' (I can't justify this - if you can you should give a lot more credence to this answer).
'ached' with letters rearranged gives 'chaed'.
'chaed' enclosing 'f' is 'CHAFED'.
Can you help me to learn more?
(Other definitions for chafed that I've seen before include "Abraded by rubbing" , "Irritated by rubbing" , "Rubbed" , "Became sore from rubbing" , "Made sore from rubbing" .)