From square one
'from square one' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for anew that I've seen before include "Once more (poetic)" , "Wane in a different way, again" , "Again but differently" , "Afresh" , "From the beginning again" .)
(Other definitions for de novo that I've seen before include "Once more, again - in Latin phrase" , "From scratch" , "afresh" , "Anew (Latin)" .)