From time to time, vaccinee may develop skin condition (4)

I believe the answer is:

acne

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'skin condition' is the definition.
(I've seen this before)

'from time to time vaccinee' is the wordplay.
'from time to time' indicates alternate letters (letters removed on a regular basis).
The alternate letters of 'vaccinee' are 'ACNE'.

'may develop' is the link.
This may not be correct. Some or all of it may belong to another bit of the clue.

Can you help me to learn more?

(Other definitions for acne that I've seen before include "Pimply skin condition of adolescence" , "Skin problem, mainly of teenagers" , "Problem to face in" , "Cane for the teenager?" , "Facial spots" .)

I've seen this clue in The Irish Times.

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