Frustrate artist plugging song the wrong way (6)
I believe the answer is:
derail
'frustrate' is the definition.
(I've seen this in another clue)
'artist plugging song the wrong way' is the wordplay.
'artist' becomes 'RA' (Royal Academician, member of Royal Academy of Arts).
'plugging' indicates putting letters inside (I've seen this in other clues).
'song' becomes 'lied' (type of German song).
'the wrong way' says the letters should be written backwards.
'lied' in reverse letter order is 'deil'.
'ra' put within 'deil' is 'DERAIL'.
(Other definitions for derail that I've seen before include "go off track" , "stop things going smoothly" , "Of train, force off tracks" , "Cause to come off the tracks" , "put off track" .)