Fuss made by Dorothy about nothing (2-2)
I believe the answer is:
to-do
'fuss' is the definition.
(I've seen this before)
'by dorothy about nothing' is the wordplay.
'by' says to put letters next to each other.
'dorothy' becomes 'dot' (nickname for someone called Dorothy).
'about' is a reversal indicator.
'nothing' becomes 'O' (O resembles 0).
'dot' reversed gives 'tod'.
'tod'+'o' is 'TO-DO'.
'made' acts as a link.
(Other definitions for to-do that I've seen before include "Kerfuffle" , "Fuss or commotion" , "Fuss and bother" , "Flap" , "Quarrel" .)