Gamble of career is in chest (3,1,4)
I believe the answer is:
run a risk
'gamble' is the definition.
(synonyms)
'career is in chest' is the wordplay.
'career' becomes 'run' (career can mean to run or move out of control).
'in' means one lot of letters goes inside another.
'chest' becomes 'ark' (historical term for a chest).
'is' going within 'ark' is 'arisk'.
'run'+'arisk'='RUN A RISK'
'of' is the link.
(Another definition for run a risk that I've seen is " take chances".)
I've seen this clue in The Telegraph.
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