Game hack defending saucy newspaper strip (6,4)
I believe the answer is:
rupert bear
'newspaper strip' is the definition.
(Daily Express comic strip)
'game hack defending saucy' is the wordplay.
'game' becomes 'RU' (rugby union).
'hack' becomes 'bear' (both can mean to be able to tolerate or stand).
'defending' means one lot of letters goes inside another.
'saucy' becomes 'pert' (synonyms).
'ru'+'bear'='rubear'
'rubear' placed around 'pert' is 'RUPERT BEAR'.
(Other definitions for rupert bear that I've seen before include "Cuddly character" , "character wearing check trousers" , "Ursine comic hero" , "Cartoon character" , "Children's comic strip character, going strong since 1920" .)