Game many take to (5)
I believe the answer is:
lotto
'game' is the definition.
(lotto is a kind of game)
'many take to' is the wordplay.
'many' becomes 'lot' (I've seen this before).
'take' is a charade indicator (letters next to each other).
'lot'+'to'='LOTTO'
(Other definitions for lotto that I've seen before include "Game in which numbers are drawn" , "Game like bingo" , "Children's game; lottery" , "house" , "chancy business" .)