Game to upset a spiteful woman (6)
I believe the answer is:
tipcat
'game' is the definition.
(I've seen this before)
'upset a spiteful woman' is the wordplay.
'upset' becomes 'tip' (I've seen this in another clue).
'a spiteful woman' becomes 'cat' (I've seen this in another clue).
'tip'+'cat'='TIPCAT'
'to' acts as a link.
(Other definitions for tipcat that I've seen before include "Game" , "Hint" .)