General discomfort handicaps Sean moving around (5,3,5)
I believe the answer is:
aches and pains
'general discomfort' is the definition.
(uncomfortable feelings)
'handicaps sean moving around' is the wordplay.
'moving around' indicates anagramming the letters.
'handicaps'+'sean'='handicapssean'
'handicapssean' anagrammed gives 'ACHES AND PAINS'.
(Other definitions for aches and pains that I've seen before include "Muscular problems" , "A visit to no.13 [CLINIC] might be necessary after" , "bodily discomfort" , "Minor physical discomforts" , "nagging discomfort" .)