George Herman Ruth, familiarly (4)
I believe the answer is:
babe
'george herman ruth familiarly' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for babe that I've seen before include "A literary newborn, or a modern good-looking woman" , "Very young child (often found in arms)" , "Girlfriend" , "Pretty Woman" , "Ruth, for example" .)