George Weasley, say, gets extremely grave pain (6)
I believe the answer is:
twinge
'pain' is the definition.
(twinge is a kind of pain)
I cannot understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for twinge that I've seen before include "Sudden sharp pain" , "Slight localised pain" , "Emotional pang" , "little pain" , "Sharp localised pain" .)