Georgian perhaps runs three trips round Ohio (10)
I believe the answer is:
southerner
'georgian perhaps' is the definition.
(Georgia is in the US South)
'runs three trips round ohio' is the wordplay.
'trips' indicates an anagram.
'round' is an insertion indicator.
'ohio' becomes 'o'.
'runs'+'three'='runsthree'
'runsthree' with letters rearranged gives 'sutherner'.
'sutherner' enclosing 'o' is 'SOUTHERNER'.
(Other definitions for southerner that I've seen before include "One from lower down the country" , "Alabaman" .)