Gesture to mix gins (4)
I believe the answer is:
sign
'gesture' is the definition.
(I know that sign is a type of gesture)
'mix gins' is the wordplay.
'mix' is an anagram indicator.
'gins' with letters rearranged gives 'SIGN'.
'to' acts as a link.
(Other definitions for sign that I've seen before include "Evidence" , "As the star was for 14 across" , "Notice; omen" , "Token - symbol - omen - write one's name" , "Endorse" .)