Get out of the way of a vacuum (5)
I believe the answer is:
avoid
'get out of the way of' is the definition.
(I've seen this in another clue)
'a vacuum' is the wordplay.
'vacuum' becomes 'void' (I've seen this in another clue).
'a'+'void'='AVOID'
(Other definitions for avoid that I've seen before include "Desist" , "Refrain from (something)" , "Shy away from" , "Stay clear of" , "Bypass" .)