Get rid of drug, creating ticklish situation (6)
I believe the answer is:
scrape
'ticklish situation' is the definition.
(a tricky situation or predicament)
'get rid of drug' is the wordplay.
'get rid of' becomes 'scrap' (I've seen this before).
'drug' becomes 'e' (e is another name for ecstasy).
'scrap'+'e'='SCRAPE'
'creating' is the link.
(Other definitions for scrape that I've seen before include "stroke of a violin" , "Thinly applied butter - or jam!" , "Tricky situation - graze" , "Abrade - economise" , "Rasp or abrade" .)