Get rid of wicked and spiteful woman (3-5)
I believe the answer is:
she-devil
'spiteful woman' is the definition.
(I've seen this before)
'get rid of wicked' is the subsidiary indication.
'get rid of' becomes 'shed' (I've seen this before).
'wicked' becomes 'evil' ('evil' can be a synonym of 'wicked').
'shed'+'evil'='shedevil'
'and' is the link.
(Other definitions for she-devil that I've seen before include "Malicious and spiteful woman" , "woman like Lilith" .)