Girl from Harlem, Manhattan (4)
I believe the answer is:
emma
'girl' is the definition.
'from harlem manhattan' is the wordplay.
'from' says the answer is hidden in the clue.
'EMMA' is hidden within 'harlem manhattan'.
(Other definitions for emma that I've seen before include "Female" , "Titled heroine" , "Ack -, a term for a.m." , "J Austen novel" , "young woman in novel" .)