Girl going to university with a large book (6)
I believe the answer is:
annual
'book' is the definition.
(annual is a kind of book)
'girl going to university with a large' is the wordplay.
'girl' becomes 'ann' (woman's name).
'going to' says to put letters next to each other.
'university' becomes 'U' (abbreviation as in UMass).
'with' is a charade indicator (letters next to each other).
'large' becomes 'L' (eg in clothes sizes).
'ann'+'u'+'a'+'l'='ANNUAL'
(Other definitions for annual that I've seen before include "Occuring once a year" , "Coming once a year" , "Reference book that's published every year" , "Occurring yearly" , "Lasting for a year" .)