Girl set out with van, one that's utterly empty (10)
I believe the answer is:
starveling
'one that's utterly empty' is the definition.
(a starveling is a starving person)
'girl set out with van' is the wordplay.
'out with' indicates anagramming the letters (out can mean wrong or inaccurate).
'girl'+'set'='girlset'
'girlset' with its letters mixed up with 'van' makes 'STARVELING'.
(Other definitions for starveling that I've seen before include "Character in A Midsummer Night's Dream" , "Athens tailor (AMND)" , "famished child" , "Ill-fed man" , "Shakespeare's tailor" .)