Girl's beads hold me up
I believe the answer is:
rosemary
'girl's' is the definition.
'beads hold me up' is the wordplay.
'beads' becomes 'rosary' (rosary is a kind of beads).
'hold' is an insertion indicator.
'up' shows that the letters should be reversed in order (in down clue: letters go upwards).
'me' backwards is 'em'.
'rosary' placed around 'em' is 'ROSEMARY'.
(Other definitions for rosemary that I've seen before include "Name of girl or herb" , "Fragrant evergreen shrub and herb" , "Helps one to remember" , "Plant" , "Shrub of the mint family" .)