Give a false account of various enterprises supporting millions (12)
I believe the answer is:
misrepresent
'give a false account of' is the definition.
(I've seen this before)
'various enterprises supporting millions' is the wordplay.
'various' indicates an anagram.
'supporting' means one lot of letters go next to another (in a down clue, some letters go below others).
'millions' becomes 'm' (abbreviation).
'enterprises' with letters rearranged gives 'isrepresent'.
'isrepresent' put after 'm' is 'MISREPRESENT'.
(Other definitions for misrepresent that I've seen before include "Give inaccurate portrayal" , "Give a false account of (something)" , "Falsely state" .)