Give first of benzedrine tablets to wife (6)
I believe the answer is:
bestow
'give' is the definition.
(bestowing is a kind of giving)
'first of benzedrine tablets to wife' is the wordplay.
'first of benzedrine' becomes 'b' (1st letter of 'benzedrine').
'tablets' becomes 'es' (E can refer to an ecstasy tablet).
'wife' becomes 'w'.
'b'+'es'+'to'+'w'='BESTOW'
(Other definitions for bestow that I've seen before include "Confer, donate" , "Give as a gift" , "Award, present as a gift" , "Present, donate" , "Confer (an honour)" .)