Give up a random ride round a resort (7)
I believe the answer is:
despair
'give up' is the definition.
(thesaurus)
'a random ride round a resort' is the wordplay.
'a random' indicates an anagram.
'round' is an insertion indicator.
'a resort' becomes 'spa' (spa is a kind of resort).
'ride' anagrammed gives 'deir'.
'deir' going around 'spa' is 'DESPAIR'.
(Other definitions for despair that I've seen before include "Total loss of hope" , "Despondency" , "Abandon hope" , "Despond" , "Opposite of 10" .)