Give up burden (7)
I believe the answer is:
refrain
I believe this is a double definition.
'give up' is the first definition.
(thesaurus)
'burden' is the second definition.
(thesaurus)
(Other definitions for refrain that I've seen before include "Main theme" , "The repeated lines at the end of verses" , "burden" , "tune" , "recurring phrase" .)