Give up completely; desert (7)
I believe the answer is:
abandon
I believe this is a double definition.
'give up completely' is the first definition.
(I've seen this before)
'desert' is the second definition.
(synonyms)
(Other definitions for abandon that I've seen before include "Desert; lack of restraint" , "Total lack of inhibition (often gay?)" , "Give up; leave behind" , "Forsake with recklessness" , "Cast aside" .)