Give up, inside spa, Irish bottles (7)
I believe the answer is:
despair
'give up' is the definition.
(I've seen this in another clue)
'inside spa irish bottles' is the wordplay.
'bottles' indicates the answer is hidden within the clue (bottling is a kind of containing).
'DESPAIR' is hidden within 'inside spa irish'.
(Other definitions for despair that I've seen before include "Give up hope" , "Lose or lack hope" , "Praised (anag) - lose hope" , "An unhappy state" , "Hopeless" .)