Give up, utterly without energy (4)
I believe the answer is:
quit
'give up' is the definition.
(both can mean to resign)
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for quit that I've seen before include "Leave office" , "Abandon, depart" , "Leave - resign" , "Decamp" , "Leave or abandon" .)