Give way at 100th Avenue (4)
I believe the answer is:
cave
'give way' is the definition.
(thesaurus)
'at 100th avenue' is the wordplay.
'at' means one lot of letters go next to another.
'c00th' becomes 'c' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'avenue' becomes 'ave'.
'c' next to 'ave' is 'CAVE'.
Can you help me to learn more?
(Other definitions for cave that I've seen before include "Troglodyte's home" , "Beware" , "Watch out" , "Natural underground chamber" , "Aladdin, Fingal, had one" .)