Giving employment to American in centre of Zhangzhou (5)
I believe the answer is:
using
'giving employment to' is the definition.
(to use something is to employ it)
'american in centre of zhangzhou' is the wordplay.
'american' becomes 'us' (abbreviation for United States).
'centre of' says to take the centre.
The central letter of 'zhangzhou' is 'g'.
'us'+'in'+'g'='USING'
(Other definitions for using that I've seen before include "having recourse to" , "Exercising" , "Exploiting for one's own advantage" , "addiction" , "Putting to a particular purpose" .)