Go down and look over the southeast (4)
I believe the answer is:
lose
'go down' is the definition.
(I've seen this before)
'look over the southeast' is the wordplay.
'look' becomes 'lo'.
'over' is a charade indicator (letters next to each other).
'the southeast' becomes 'se' ('SE' can be a synonym of 'southeast').
'lo'+'se'='LOSE'
'and' is the link.
(Other definitions for lose that I've seen before include "Mislay - fail" , "Don't win" , "Cease to have" , "Fail to win" , "Mislay or be defeated" .)