Go, drunken varlet! (6)
I believe the answer is:
travel
'go' is the definition.
(synonyms)
'drunken varlet' is the wordplay.
'drunken' is an anagram indicator.
'varlet' is an anagram of 'TRAVEL'.
(Other definitions for travel that I've seen before include "It is said to broaden the mind" , "Go on a journey" , "Go from place to place" , "Voyage" , "Pass" .)