Go for broke then give up (5)
I believe the answer is:
forgo
'give up' is the definition.
(I know that give up can be written as forgo)
'go for broke' is the wordplay.
'broke' is an anagram indicator.
'go'+'for'='gofor'
'gofor' with letters rearranged gives 'FORGO'.
'then' acts as a link.
(Other definitions for forgo that I've seen before include "Do without (something desirable)" , "Go without (something)" , "pass up" , "Waive" , "Relinquish, give up" .)