Go into heart of America, spending cents (5)
I believe the answer is:
enter
'go into' is the definition.
(enter can mean to go into a place)
'heart of america spending cents' is the wordplay.
'heart of america' becomes 'center' (US spelling of 'center').
'spending' indicates named letters should be taken away (to spend can mean to give out or give away).
'cents' becomes 'c' (abbreviation for cents).
'center' with 'c' removed is 'ENTER'.
(Other definitions for enter that I've seen before include "Register (as a competitor)" , "Gain admission" , "Enroll, sign up" , "Come or go in" , "Go in and put in the ledger" .)