Go off with a schedule (4)
I believe the answer is:
rota
'schedule' is the definition.
(I've seen this before)
'go off with a' is the wordplay.
'go off' becomes 'rot' (as in food going off).
'with' means one lot of letters go next to another.
'rot'+'a'='ROTA'
(Other definitions for rota that I've seen before include "Ecclesiastical tribunal" , "Working times list" , "Task list, roster" , "supreme Catholic court" , "Duty schedule" .)