Goa beast on the loose causes destruction (8)
I believe the answer is:
sabotage
'destruction' is the definition.
(I know that sabotage is a type of destruction)
'goa beast on the loose' is the wordplay.
'on the loose' is an anagram indicator.
'goa'+'beast'='goabeast'
'goabeast' anagrammed gives 'SABOTAGE'.
'causes' is the link.
(Other definitions for sabotage that I've seen before include "malicious damage" , "Disrupt" , "Scupper" , "spoil things" , "Subversion by inflicting damage" .)