Goddess is after Spanish agreement being lifted (4)
I believe the answer is:
isis
'goddess' is the definition.
(Egyptian god)
'is after spanish agreement being lifted' is the wordplay.
'after' says to put letters next to each other.
'spanish agreement' becomes 'si' (Spanish for yes).
'being lifted' says the letters should be written in reverse (going up in down clue).
'si' backwards is 'is'.
'is'+'is'='ISIS'
(Other definitions for isis that I've seen before include "Oxford's second crew" , "Egyptian goddess and jihadist group" , "To be, to be an Egyptian goodess" , "Egyptian goddess of nature" , "God" .)