Goddess often depicted holding an ankh (4)
I believe the answer is:
isis
'goddess often depicted holding an ankh' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for isis that I've seen before include "A dark blue flower" , "Mrs Osiris" , "Si, si - an Egyptian goddess" , "Jihadists" , "Oxford river; goddess" .)