Goddess with multiple lives (4)
I believe the answer is:
isis
'goddess' is the definition.
(Egyptian god)
'with multiple lives' is the wordplay.
'multiple lives' can mean two replacements for 'lives'.
'with' is a charade indicator (letters next to each other).
'lives' becomes 'is' ('be' can be a synonym of 'live').
'lives' becomes 'is' ('be' can be a synonym of 'live').
'is' next to 'is' is 'ISIS'.
(Other definitions for isis that I've seen before include "Goddess of the rainbow" , "Part of river" , "Repetitive Egyptian goddess" , "divinity" , "Old Egyptian fertility goddess" .)