Good lady cleverly circumvents female troublemaker (6)
I believe the answer is:
gadfly
'troublemaker' is the definition.
(I've seen this before)
'good lady cleverly circumvents female' is the wordplay.
'good' becomes 'g' (abbreviation).
'cleverly' indicates an anagram.
'circumvents' indicates putting letters inside.
'female' becomes 'f' (abbreviation).
'lady' with letters rearranged gives 'adly'.
'adly' going around 'f' is 'adfly'.
'g'+'adfly'='GADFLY'
(Other definitions for gadfly that I've seen before include "Pestering insect" , "Small insect that bites horses and cattle" , "Bloodsucker; nuisance" , "Insect; annoying person" , "Persistently annoying person" .)