Good-natured family departs (4)
I believe the answer is:
kind
'good-natured' is the definition.
('kind' is associated in meaning with 'good-natured')
'family departs' is the wordplay.
'family' becomes 'kin' ('kin' can be a synonym of 'family'**).
'departs' becomes 'd' (common abbreviation e.g. train timetables).
'kin'+'d'='KIND'
(Other definitions for kind that I've seen before include "Generous - sort" , "Taking a plunge" , "Character, nature" , "Benevolent - sort" , "Friendly, generous and considerate" .)