Government, in disarray, isn't being held in high regard (14)
I believe the answer is:
administration
'government' is the definition.
('administration' can be a synonym of 'government')
'disarray isn't being held in high regard' is the subsidiary indication.
'disarray' indicates an anagram.
'being held in' means one lot of letters goes inside another.
'high regard' becomes 'admiration' (I've seen this before).
'isnt' anagrammed gives 'nist'.
'nist' going within 'admiration' is 'administration'.
'in' is the link.
(Other definitions for administration that I've seen before include "government in power" , "Running a business" .)