GP, say, keeping various items around the house (8)
I believe the answer is:
domestic
'around the house' is the definition.
'gp say keeping various items' is the wordplay.
'gp say' becomes 'doc' (general practitioner is a type of doctor).
'keeping' indicates putting letters inside.
'various' is an anagram indicator.
'items' with letters rearranged gives 'mesti'.
'doc' placed around 'mesti' is 'DOMESTIC'.
(Other definitions for domestic that I've seen before include "Homely" , "of houses?" , "Relating to the household" , "Argument - in the home" , "violent incident at home" .)