Gradual stage run using a sweetener (10,5)
I believe the answer is:
granulated sugar
'a sweetener' is the definition.
(I know that granulated sugar is a type of sugar)
'gradual stage run using' is the wordplay.
'using' indicates anagramming the letters (the letters used in a different way).
'gradual'+'stage'+'run'='gradualstagerun'
'gradualstagerun' anagrammed gives 'GRANULATED SUGAR'.
(Other definitions for granulated sugar that I've seen before include "White sweetener" , "sweetener needed" .)