Gran and I in awful fix (7)
I believe the answer is:
'fix' is the definition.
(I've seen this before)
'gran and i in awful' is the wordplay.
'and' is a charade indicator (letters next to each other).
'awful' is an anagram indicator.
'gran' after 'iin' is 'iingran'.
'iingran' is an anagram of 'INGRAIN'.
(Other definitions for ingrain that I've seen before include "Fix", "Plant firmly", "Firmly instil", "Impress deeply on the mind", "Drive home".)