Gran and I in awful fix (7)
I believe the answer is:
ingrain
'fix' is the definition.
(I've seen this before)
'gran and i in awful' is the wordplay.
'and' is a charade indicator (letters next to each other).
'awful' is an anagram indicator.
'i'+'in'='iin'
'gran' after 'iin' is 'iingran'.
'iingran' is an anagram of 'INGRAIN'.
(Other definitions for ingrain that I've seen before include "Impress deeply on the mind" , "Fix" , "dye thus" , "Firmly instil" , "deeply impressed" .)